Coursera - Virology I: How Viruses Work (Columbia University)
WEBRip | English | MP4 + PDF Guides | 960 x 540 | VP8 ~565 kbps | 25 fps
Vorbis | 128 Kbps | 48.0 KHz | 2 channels | 02:07:42 | 3.72 GB
Genre: eLearning Video / Science, Biology and Genetics
This introductory virology course emphasizes the common reactions that must be completed by all viruses for successful reproduction within a host cell and survival and spread within a host population. The molecular basis of alternative reproductive cycles are presented with examples drawn from a set of representative animal and human viruses, although selected bacterial viruses will be discussed.
SyllabusWeek 1Welcome to virology
What is a virus?
Viruses then and now
Week 2The infectious cycle
Assay of viral infectivity
Measurement of virions and their components
Revolutionary methods
One-step growth cycle
Week 3The Baltimore scheme
DNA virus genomes
RNA virus genomes
Viral genetics
Week 4Structure
The tools of structural virology
Helical symmetry
Icosahedral symmetry
Enveloped virions
Complex virions
Week 5Attachment to cells
Entry into cells
Acid-catalyzed fusion
A new paradigm for entry
Entry of non-enveloped virions
Entering the nucleus
Week 6Viral RNA synthesis
RNA polymerization
Plus strand RNA synthesis
Negative strand RNA synthesis
RNA synthesis of dsRNA genomes
RNA synthesis as a source of diversity
Week 7DNA basics
Lessons from SV40
Priming via DNA or protein
Viral origins
Big DNA viruses
Regulation of DNA synthesis
Week 8Transcription
Initiation of transcription
Viral transcription regulation
Capping and polyadenylation
Pre-mRNA splicing
Week 9Reverse transcriptase
Retroviruses
Reverse transcription
Integration
The provirus
Hepatitis B virus
Week 10End-dependent initiation of protein synthesis
Other decoding mechanisms
One mRNA, one protein?
Maximizing coding capacity of the viral genome
Regulation of translation: eIF2alpha
How viruses regulate cell translation
MicroRNAs
Week 11Principles of virion assembly
Getting to the right place
Making sub-assemblies
Concerted assembly: Budding
Genome packaging
Acquisition of an envelope and egress
General
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